Zoloft vs Wellbutrin: What’s the Difference?

Zoloft vs Wellbutrin: Whats the Difference?

If you live in Canada, chances are you, or someone you know, has dealt with depression or anxiety. In fact, according to statistics, antidepressant drugs represent the largest drug category by prescription volume in Canada. 

If you’re seeking treatment for depression or anxiety, you may have come across two popular medications: Zoloft and Wellbutrin. While both are used to treat the same conditions, they work differently in the brain and have different side effects. It’s important to note that people may respond differently to these medications, and there is no “one-size-fits-all” solution for mental health.

That being said, understanding the differences between Zoloft vs. Wellbutrin can help you make an informed decision with the help of your healthcare provider.

What is Zoloft?

Zoloft is a medicine that doctors often give to people who are experiencing depression or anxiety (and other similar mental health conditions). It’s part of a group of drugs called selective serotonin reuptake inhibitors, or SSRIs for short.

To understand how Zoloft works, you need to know about serotonin. Serotonin is a chemical in your brain that helps control your mood, hunger, and sleep. Zoloft helps by making more serotonin available in your brain, which can help you feel better.

One of the benefits of Zoloft is that it has been extensively studied and proven effective for treating a range of mental health conditions. It is also generally well-tolerated with fewer side effects than older antidepressants. Zoloft has also been shown to have a lower drug interaction risk than other antidepressants, such as MAOIs.

But like all medicines, Zoloft can have some downsides. Some people might feel sick, dizzy, or have trouble sleeping when taking Zoloft. It can also cause problems with sexual function (although that’s typical with SSRIs). Plus, it might not work for everyone and might not be the best choice if you have certain health issues.

That’s why it’s so important to consult a medical doctor. At the very least, you should be speaking with a pharmacist at your local Canadian pharmacy or US pharmacy. Other medicines work differently than Zoloft, meaning it isn’t your only option for combatting depression and anxiety.

What is Wellbutrin?

Wellbutrin is another medication often used to treat depression. It works similarly by altering certain brain chemicals that influence our mood. The drug’s scientific name is bupropion, and it belongs to a class of drugs known as norepinephrine-dopamine reuptake inhibitors (NDRI).

How does it work? Again, it’s similar to Zoloft. Essentially, it helps maintain the balance of two brain chemicals, norepinephrine, and dopamine, which play key roles in regulating our mood and motivation.

A significant benefit of Wellbutrin compared to other antidepressants is that it typically doesn’t lead to sexual side effects. This is because Wellbutrin doesn’t impact serotonin levels in the brain (like Zoloft might). Serotonin plays a crucial role in sexual function.

Another perk of Wellbutrin is that it generally doesn’t result in weight gain, another frequent side effect of numerous antidepressants. Some individuals have even reported losing weight while taking this medication. However, some people have reported experiencing more side effects with Wellbutrin than with other antidepressants, including:

  • Headaches
  • Trouble sleeping
  • Increased anxiety

Furthermore, those with a history of seizures should avoid Wellbutrin. It can heighten the risk of experiencing seizures in some patients.

Overall, Wellbutrin can be an effective choice for those seeking an antidepressant that doesn’t provoke sexual side effects or weight gain. However, it may not be suitable for everyone. It’s crucial to discuss your specific needs and medical history with your doctor to determine the best treatment strategy for you.

Zoloft vs. Wellbutrin

Now, regarding Zoloft vs. Wellbutrin, which is the best for you? Here’s a simple breakdown to help you decide:


  • Works as a selective serotonin reuptake inhibitor (SSRI)
  • As an SSRI, it increases the levels of serotonin in your brain
  • Often prescribed for anxiety disorders, depression, and post-traumatic stress disorder (PTSD)
  • Takes four to six weeks to start working
  • Side effects may include nausea, sleepiness, and sexual dysfunction
  • Can be habit-forming


  • Works as a norepinephrine-dopamine reuptake inhibitor (NDRI)
  • As an NDRI, it increases the levels of norepinephrine and dopamine in your brain
  • Often prescribed for depression and seasonal affective disorder (SAD)
  • Typically starts working within one to two weeks
  • Side effects may include dry mouth, headache, and insomnia
  • Not habit-forming

So, how do you choose between Wellbutrin vs. Zoloft if these factors don’t necessarily apply to you? Talk to your doctor. They can assess your symptoms and medical history to determine the best medication for you.

Overall, it’s helpful to consider your symptoms, too. Zoloft is better for anxiety, while Wellbutrin is better for depression. Think about the side effects, though. As mentioned, Zoloft can cause sexual dysfunction, while Wellbutrin can cause insomnia.

And finally, remember that both medications take time to work. You may not see improvement for several weeks, so be patient and diligent with taking your medication as prescribed.

How to Get Medication

Ready to try Zoloft or Wellbutrin to help ease your symptoms? We support that. Getting the right medication from Canada can improve your mental health journey. However, in Canada, you need a prescription to get medications like Zoloft or Wellbutrin. Heres what you need to know to get the right medication.

Firstly, youll need to see a doctor or psychiatrist. They can assess your symptoms and prescribe the appropriate medication for you. Being honest about your symptoms and concerns is important, as this will help your healthcare provider make an accurate diagnosis.

Once you have your prescription, you can take it to a Canadian pharmacy to fill it. Some pharmacies offer online ordering (like onlinecanadianpharmacy.com), so you can even get your medication delivered to your door.

Its important to take your medication as prescribed by your healthcare provider. This will ensure that you get the full benefit of the medication and minimize any potential side effects. Its also important to note that your insurance plan may not cover some medications. Always check with your healthcare provider and insurance company to understand potential costs.

Stay Healthy

The Zoloft vs. Wellbutrin debate is the only thing you need to consider when caring for your mental health. Taking medication can help, sure. However, learning other techniques and coping strategies can help ensure you’re caring for your mental health and well-being regardless of the medication you get.

If you’re struggling with where to start, read this helpful guide titled “5 Ways to Prioritize Your Mental Health.”

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